- ￥880
- Bioss
- bs-12316P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-12316P |
| 英文名称 | HHIP Antibody Blocking Peptide |
| 中文名称 | HHIP蛋白封闭多肽 |
| 英文别名 | FLJ20992; FLJ90230; Hedgehog interacting protein; Hedgehog-interacting protein; hedgehoginteracting protein; HHIP; HHIP_HUMAN; HIP. |
| 纯化方法 | HPLC |
| 研究领域 | Stem Cells > Signaling Pathways > Hedgehog > Secreted Stem Cells > Signaling Pathways > Hedgehog > Surface Molecules |
| 亚基 | Interacts with all three hedgehog family members, SHH, IHH and DHH. |
| 亚细胞定位 | Cytoplasm and Cell membrane. Secreted. The last 22 C-terminal amino acids may participate in cell membrane attachment. |
| 组织特异性 | Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney. |
| 相似性 | Belongs to the HHIP family. Contains 2 EGF-like domains. |
| 功能 | Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Hedgehog (Hh) signaling proteins are critical for growth and tissue patterning during development. Patched (Ptc), a putative 12 transmembrane receptor, binds to Sonic hedgehog and is suspected to be a negative regulator of Hh signaling. A family member of patched, designated patched 2, has been found to be co-expressed with Sonic hedgehog. Smoothened (Smo), a seven transmembrane receptor, is complexed with patched in many tissues and is believed to be an essential component in the Hh signaling pathway. Hhip (hedgehog-interacting protein) is able to bind to and may be a transcriptional target of all Hh proteins. Binding of Hhip to Hh proteins attenuates hedgehog signaling. |
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HHIP Antibody Blocking Peptide(bs-12316P)-500ug
￥880
