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- Bioss
- bs-13592P
- 2025年10月16日
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500ug
| 产品编号 | bs-13592P |
| 英文名称 | IRF6 Antibody Blocking Peptide |
| 中文名称 | 干扰素调节因子6封闭多肽 |
| 英文别名 | Interferon regulatory factor 6; IRF 6; IRF-6; IRF6_HUMAN; LPS; OFC 6; OFC6; OTTHUMP00000034677; OTTHUMP00000034678; PIT; PPS; PPS1; VWS; VWS1. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > Helix-Turn-Helix Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Immunology > Innate Immunity > Cytokines > Interferons Stem Cells > Embryonic Stem Cells > Cytokines |
| 亚细胞定位 | Nucleus. Cytoplasm. Translocates to nucleus in response to an activating signal. |
| 组织特异性 | Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. |
| 翻译后修饰 | Phosphorylated. Phosphorylation status depends on the cell cycle and is a signal for ubiquitination and proteasome-mediated degradation. |
| 相似性 | Belongs to the IRF family. Contains 1 IRF tryptophan pentad repeat DNA-binding domain. |
| 功能 | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-alpha and beta) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-alpha and interferon-beta genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth; overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3 gamma p48 and IFN consensus sequence-binding protein (ICSBP). |
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IRF6 Antibody Blocking Peptide(bs-13592P)-500ug
￥880
