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- bs-7689P
- 2025年10月16日
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500ug
| 产品编号 | bs-7689P |
| 英文名称 | KCNMB1/Maxi Potassium channel beta Antibody Blocking Peptide |
| 中文名称 | 钙激活钾通道蛋白β1封闭多肽 |
| 英文别名 | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits; KCMB1_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 组织特异性 | Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. [View classification] |
| 功能 | Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca2+/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the product of this gene, the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. [provided by RefSeq, Jul 2008] |
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KCNMB1/Maxi Potassium channel beta Antibody Blocking Peptide(bs-7689P)-500ug
￥880
