- ￥880
- Bioss
- bs-9169P
- 2025年10月16日
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500ug
| 产品编号 | bs-9169P |
| 英文名称 | PCGF3 Antibody Blocking Peptide |
| 中文名称 | 环指蛋白3封闭多肽 |
| 英文别名 | DONG1; PCGF3; polycomb group ring finger 3; Ring finger protein 3; RNF3; RNF3A; PCGF3_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Remodeling > Polycomb Silencing Epigenetics and Nuclear Signaling > Transcription > Mediator Complex Epigenetics and Nuclear Signaling > Transcription > Transcription Factors |
| 亚基 | Component of a PRC1-like complex. Interacts with CBX6, CBX7 and CBX8. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Contains 1 RING-type zinc finger. |
| 功能 | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation. PCGF3 (polycomb group ring finger 3), also known as RNF3, DONG1 or RNF3A, is a 242 amino acid transcriptional regulator that is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. PCGF3 exists as two isoforms produced by alternative splicing events. |
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PCGF3 Antibody Blocking Peptide(bs-9169P)-500ug
￥880
