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- Bioss
- bs-16353P
- 2025年10月16日
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500ug
| 产品编号 | bs-16353P |
| 英文名称 | GTF2H4 Antibody Blocking Peptide |
| 中文名称 | 通用转录因子2H亚基4/TFIIH p52封闭多肽 |
| 英文别名 | Basic transcription factor 2 52 kDa subunit; Basic transcription factor 52 kDa subunit; BTF2 p52; General transcription factor IIH polypeptide 4 52kDa; General transcription factor IIH polypeptide 4 52kDa subunit; General transcription factor IIH polypeptide 4 52kDa variant; General transcription factor IIH polypeptide 4; General transcription factor IIH subunit 4; Gtf2h4; OTTHUMP00000029049; OTTHUMP00000164874; P52; TF2H4_HUMAN; TFB2; TFIIH basal transcription factor complex p52 subunit; TFIIH protein; TIFIIH; Transcription factor II H; Transcription factor IIH 52 kDa subunit. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Cytoplasm. Nucleus. Colocalizes with BTK in the cytoplasm. |
| 组织特异性 | Ubiquitous. Isoform 1 is strongly expressed in fetal brain, weakly in adult brain, muscle, and lymphoblasts and is almost undetectable in other adult tissues, while the other isoforms are equally expressed in all adult tissues. |
| 翻译后修饰 | Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation. Sumoylated. |
| 相似性 | Belongs to the TFII-I family. Contains 6 GTF2I-like repeats. |
| 功能 | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TFII I is a ubiquitously expressed multifunctional transcription factor with broad biological roles in transcription and signal transduction in a variety of cell types. It has been shown that TFII I can interact physically and functionally with Btk (Bruton's tyrosine kinase), a hematopoietic non-receptor protein tyrosine kinase that is critical for B lymphocyte development. |
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GTF2H4 Antibody Blocking Peptide(bs-16353P)-500ug
￥880
