- ￥880
- Bioss
- bs-16351P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-16351P |
| 英文名称 | GTF2H2C Antibody Blocking Peptide |
| 中文名称 | 通用转录因子2H亚基2C封闭多肽 |
| 英文别名 | General transcription factor IIH polypeptide 2-like protein; General transcription factor IIH polypeptide 2C; General transcription factor IIH subunit 2-like protein; GTF2H2D; T2H2L_HUMAN. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Nucleus. |
| 相似性 | Belongs to the GTF2H2 family. Contains 1 VWFA domain. |
| 功能 | Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFIIH. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of 5 subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34 . Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair. |
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GTF2H2C Antibody Blocking Peptide(bs-16351P)-500ug
￥880
