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- Bioss
- bs-3516P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-3516P |
| 英文名称 | MLXIPL Antibody Blocking Peptide |
| 中文名称 | 糖类应答元件结合蛋白ChREBP封闭多肽 |
| 英文别名 | ChREBP; bHLHd14; Carbohydrate responsive element binding protein; MIO; MLX interacting protein like; Mlx interactor; MONDOB; WBSCR 14; WBSCR14; MLXIPL;Williams Beuren syndrome chromosome region 14; Williams Beuren syndrome chromosome region 14 protein; WS basic helix loop helix leucine zipper protein; WS bHLH; MLXPL_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Metabolic signaling pathway > Integration of energy metabolism Cardiovascular > Atherosclerosis > Diabetes associated Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Metabolism > Pathways and Processes > Metabolic signaling pathways > Energy transfer pathways > Integration of energy Metabolism > Types of disease > Cancer Metabolism > Types of disease > Diabetes Metabolism > Types of disease > Heart disease |
| 亚基 | Binds DNA as a heterodimer with TCFL4/MLX. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in liver, heart, kidney, cerebellum and intestinal tissues. |
| 翻译后修饰 | Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding activity (By similarity). |
| 相似性 | Contains 1 basic helix-loop-helix (bHLH) domain. |
| 功能 | Transcriptional repressor. Binds to the canonical and non-canonical E box sequences 5'-CACGTG-3' (By similarity). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ChREBP (Carbohydrate responsive element binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NLS) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine zipper like (zip-like) domain.ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney and white and brown adipose tissue. Under basal conditions ChREBP is localized in the cytosol, translocating into the nucleus upon high glucose stimulation following its dephosphorylation of phospho-serine 196. |
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MLXIPL Antibody Blocking Peptide(bs-3516P)-500ug
￥880
