- ￥880
- Bioss
- bs-13175P
- 2025年10月16日
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500ug
| 产品编号 | bs-13175P |
| 英文名称 | FKBP10 Antibody Blocking Peptide |
| 中文名称 | 肽基脯氨酰顺反异构酶FKBP10封闭多肽 |
| 英文别名 | 65 kDa FK506 binding protein; FK506 binding protein 10 65 kDa; FK506 binding protein 10; FKBP 10; FKBP 65; hFKBP 65; Immunophilin FKBP65; Peptidyl prolyl cis trans isomerase. PPIase; Rotamase; FKB10_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Trafficking > Chaperones > Other Chaperones Tags & Cell Markers > Subcellular Markers > Organelles > ER |
| 亚细胞定位 | Endoplasmic reticulum. |
| 翻译后修饰 | Glycosylated and phosphorylated. |
| 相似性 | Contains 2 EF-hand domains. Contains 4 PPIase FKBP-type domains. |
| 功能 | FKBP10 (FK506 binding protein 10) belongs to the FKBP type peptidyl-prolyl cis/trans isomerase (PPIase) family. PPIases accelerate the folding of proteins during protein synthesis, acting as molecular chaperones. FKBP10 is located in the endoplasmic reticulum (ER) and is thought to play a role in the folding and trafficking of secretory proteins. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. Immunophilins have also been implicated in protein folding and trafficking within the endoplasmic reticulum (ER). FKBP10 (FK506-binding protein 10), also known as peptidyl-prolyl cis-trans isomerase, PPIase, Rotamase, 65kDa FK506-binding protein or FKBP65, is a 582 amino acid immunophilin localized to the ER lumen and found in many tissues including heart, spleen, brain, testis and lung. FKBP10 contains two EF-hand calcium-binding domains and four PPIase FKBP-type domains, suggesting an enzymatic role in protein folding by catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FKBP10 also acts as a receptor for the immunosuppressants FK506 and rapamycin, which inhibit FKBP10 activity. FKBP10 is thought to interact with the Raf-1/HSP 90 heterocomplex during signal transduction processes, and may associate with elastin during elastin protein folding and transport. With a valine-24 addition to human FKBP10, human and mouse FKBP10 are almost identical. |
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FKBP10 Antibody Blocking Peptide(bs-13175P)-500ug
￥880
