- ￥680 - 2500
- Bioss
- bs-36102P
- 2025年10月16日
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10ug/50ug
| 规格： | 10ug | 产品价格： | ￥680.0 |
|---|---|---|---|
| 规格： | 50ug | 产品价格： | ￥2500.0 |
| 产品编号 | bs-36102P |
| 英文名称 | Recombinant mouse Fibroblast Growth Factor-acidic protein |
| 中文名称 | 重组小鼠酸性成纤维细胞生长因子蛋白 |
| 英文别名 | Acidic fibroblast growth factor; aFGF; Beta endothelial cell growth factor; Beta-endothelial cell growth factor; ECGF; ECGF beta; ECGF-beta; ECGFA; ECGFB; Endothelial Cell Growth Factor alpha; Endothelial Cell Growth Factor beta; FGF 1; FGF alpha; FGF-alpha; FGF1_MOUSE; FGFA; Fibroblast Growth Factor 1 Acidic; Fibroblast growth factor 1; GLIO703; HBGF 1; HBGF-1; HBGF1; Heparin binding growth factor 1; Heparin-binding growth factor 1; Fibroblast Growth Factor acidic; Recombinant mouse Fibroblast Growth Factor-acidic protein |
| 性状 | Liquid |
| 纯化方法 | AC |
| 理论分子量 | 16 |
| 浓度 | ＞0.5 mg/ml |
| 储存液 | Lyophilized from sterile 50mM Na2SO4 with 0.5mM DTT, 1mM EDTA and 20mM Tris-HCl (pH7.5). |
| 研究领域 | Cancer > Growth factors > FGF Cardiovascular > Angiogenesis > Growth Factors > FGF > FGF Signal Transduction > Growth Factors/Hormones > FGF |
| 亚基 | Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. |
| 亚细胞定位 | Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59. |
| 组织特异性 | Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle. |
| 翻译后修饰 | In the nucleus, phosphorylated by PKC/PRKCD. |
| 相似性 | Belongs to the heparin-binding growth factors family. |
| 功能 | The heparin-binding fibroblast growth factors play important roles in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. They are potent mitogens in vitro. |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | FGF1 also designated Heparin-binding growth factor 1 precursor (HBGF-1) ; Acidic fibroblast growth factor (aFGF). heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. Subunit si monomer.FGF1 belongs to the heparin-binding growth factors family. may play a role in neurite outgrowth; may regulate cell differentiation in the nervous system; may act in synergy with fibronectin to enhance neuronal cell adhesion. |
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Recombinant mouse Fibroblast Growth Factor-acidic protein(bs-36102P)-10ug/50ug
￥680 - 2500
