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- Bioss
- bs-11732P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11732P |
| 英文名称 | Doppel/DPL Antibody Blocking Peptide |
| 中文名称 | 朊蛋白DPL封闭多肽 |
| 英文别名 | DPL; Dublet; MGC41841; Prion gene complex downstream; Prion like protein doppel; Prion protein 2 (dublet); Prion protein 2; Prion-like protein doppel; PRND; PRND_HUMAN; PrPLP. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease Neuroscience > Neurology process > Neurodegenerative disease > Prions |
| 亚细胞定位 | ell membrane; Lipid-anchor, GPI-anchor |
| 组织特异性 | Expressed in testis. |
| 相似性 | Belongs to the prion family. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Prion diseases or transmissible spongiform encephalopathies (TSEs) are manifested as genetic, infectious or sporadic, lethal neurodegenerative disorders involving alterations of the prion protein (PrP). Infectious PrPSc is highly expressed in the brain of animals affected by TSEs, including scrapie in sheep, BSE in cattle, and Cruetzfeldt-Jacob disease in humans. The PRND gene locus, located on human chromosome 20p, encodes for the doppel protein (Dpl), which exhibits approximately 25% sequence homology with PrP. Dpl is characterized by an alpha-helical conformation, intramolecular disulfide bonds, and two N-linked oligosaccharides, and it is presented on the cell surface by a glycosylphosphatidylinositol anchor. Dpl is highly expressed in adult testis and heart and is detectable in the brain of neonatal mice. Dpl does not appear to contribute to prion disease progression, but ectopic expression of Dpl is implicated in neuronal degeneration of ataxic PRP-deficient mice. Dpl is also thought to play a role in angiogenesis, specifically maturation of the blood-brain barrier. |
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Doppel/DPL Antibody Blocking Peptide(bs-11732P)-500ug
￥880
