- ￥880
- Bioss
- bs-14323P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-14323P |
| 英文名称 | DHX58 Antibody Blocking Peptide |
| 中文名称 | DHX58蛋白封闭多肽 |
| 英文别名 | D11LGP2; D11lgp2e; DEXH (Asp Glu X His) box polypeptide 58; DEXH box polypeptide 58; DHX 58; DHX58; DHX58_HUMAN; LGP 2; LGP2; Ortholog of mouse D11lgp2; Probable ATP dependent helicase LGP2; Probable ATP dependent RNA helicase DHX58; Probable ATP-dependent helicase LGP2; Probable ATP-dependent RNA helicase DHX58; Protein D11Lgp2 homolog; RIG-I-like receptor LGP2; RLR; RNA helicase LGP2. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing Immunology > Immune System Diseases > Antiviral Signaling |
| 亚细胞定位 | Cytoplasm. |
| 相似性 | Belongs to the helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. |
| 功能 | Participates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DHX58, is a 678 amino acid protein belonging to the helicase family. LGP2 acts as a negative regulator of host innate immune defense against viruses by binding dsRNA produced during viral replication. The repressor domain of LGP2 binds to RIG-I, a signaling protein involved in host defenses against hepatitis C virus (HCV). By preventing RIG-I multimerization, LGP2 negatively regulates RIG-I-mediated signaling. Localized to the cytoplasm, LGP2 contains one helicase ATP-binding domain and one helicase C-terminal domain. |
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DHX58 Antibody Blocking Peptide(bs-14323P)-500ug
￥880
