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- Bioss
- bs-9307P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-9307P |
| 英文名称 | CP110 Antibody Blocking Peptide |
| 中文名称 | 中心体蛋白110封闭多肽 |
| 英文别名 | 110 kDa centrosomal protein; Centriole associated protein; Centriolin; Centrosomal protein 110 kDa; Centrosomal protein CP110; Centrosomal protein of 110 kDa; CEP1; CEP110; CP110; CP110_HUMAN; DKFZp781G1416; FAN; KIAA0419; CCP110. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell cycle > Cell division Cell Biology > Cell Cycle > Cell Division > Cytokinesis Cell Biology > Cell Cycle > Cell Division > Spindle Tags & Cell Markers > Subcellular Markers > Organelles > Centrosome |
| 亚基 | Interacts with CALM1, CETN2, CEP76 and CEP97. Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to centrioles. |
| 亚细胞定位 | Cytoplasm, cytoskeleton, centrosome, centriole. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis. |
| 组织特异性 | Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. |
| 翻译后修饰 | Phosphorylated by CDKs. Ubiquitinated by the SCF(Cyclin F) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. |
| 功能 | Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. [SUBUNIT] |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Necessary for centrosome duplication at different stages of procentriole formation. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. |
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CP110 Antibody Blocking Peptide(bs-9307P)-500ug
￥880
