- ￥880
- Bioss
- bs-0731P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-0731P |
| 英文名称 | SERPINF1 Antibody Blocking Peptide |
| 中文名称 | 色素上皮源性因子封闭多肽 |
| 英文别名 | pigment epithelium-derived factor; Serpin-F1; Stromal cell-derived factor 3; SDF-3; Caspin; Alpha 2 antiplasmin; EPC 1; EPC1; PIG 35; PIG35; Pigment epithelium derived factor; Proliferation inducing protein 35; SERPIN F1; Serpin peptidase inhibitor clade F member 1; SERPINF 1; SERPINF1; PEDF_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 亚细胞定位 | Secreted. Melanosome. Enriched in stage I melanosomes. |
| 组织特异性 | Retinal pigment epithelial cells and blood plasma. |
| 翻译后修饰 | The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity. |
| 相似性 | Belongs to the serpin family. |
| 功能 | Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Pigment epithelium derived factor, originally identified in conditioned medium of cultured human fetal retinal pigment epithelial (RPE) cells, is a neurotrophic protein that induces extensive neuronal differentiation in human Y79 retinoblastoma cells, a neoplastic counterpart of normal retinoblasts. It has been suggested that PEDF is synthesized by RPE cells and secreted into the retina interphotoreceptor matrix where it may influence development/differentiation of the neural retina. PEDF is a potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The PEDF gene is a member of the serpin gene family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity. |
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SERPINF1 Antibody Blocking Peptide(bs-0731P)-500ug
￥880
