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- Bioss
- bs-0007P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-0007P |
| 英文名称 | ADM Antibody Blocking Peptide |
| 中文名称 | 肾上腺髓质素封闭多肽 |
| 英文别名 | Adrenomedullin; ADM; ADM precursor; ADML_HUMAN. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Cancer > Signal transduction Cardiovascular > Angiogenesis > Angiogenic Factors Cardiovascular > Vasculature > Vasodilation Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Neuroscience > Neurotransmitter > Neuropeptides > More Neuropeptides Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚细胞定位 | Secreted. |
| 组织特异性 | Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. |
| 相似性 | Belongs to the adrenomedullin family. |
| 功能 | AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | Adrenomedullin, a hypotensive peptide found in human pheochromocytoma, consists of 52 amino acids, has 1 intramolecular disulfide bond, and shows a slight homology with the calcitonin gene-related peptide. It may function as a hormone in circulation control because it is found in blood in a considerable concentration. The precursor, called preproadrenomedullin, is 185 amino acids long. By RNA-blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues. Genomic ADM DNA consists of4 exons and 3 introns, with the 5-prime flanking region containing TATA, CAAT, and GC boxes. There are also multiple binding sites for activator protein-2 and a cAMP-regulated enhancer element. |
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ADM Antibody Blocking Peptide(bs-0007P)-500ug
￥980
