- ￥880
- Bioss
- bs-2680P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-2680P |
| 英文名称 | NFAM1 Antibody Blocking Peptide |
| 中文名称 | NFAM1封闭多肽 |
| 英文别名 | NFAT activation molecule 1 precursor; NFAT activation molecule 1 precursor; Calcinerin/NFAT activating ITAM containing protein; CNAIP; NFAT activation molecule 1; Calcineurin/NFAT-activating ITAM-containing protein; NFAT-activating protein with ITAM motif 1; NFAM1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > NFATs Immunology > Innate Immunity > Cytokines > Interleukins Immunology > Innate Immunity > Cytokines > TNF Superfamily Signal Transduction > Signaling Pathway > Nuclear Signaling > NFATS |
| 亚基 | Interacts with ZAP70 and SYK. No direct interaction with the B-cell antigen receptor (BCR). |
| 亚细胞定位 | Cell membrane; Single-pass type I membrane protein. Note=Partially recruited to lipid rafts upon BCR stimulation. |
| 组织特异性 | Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T cells, and lung. Expressed at low level in non-immune tissue. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 1 ITAM domain. |
| 功能 | May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | NFAM1 activates cytokine gene promoters such as the IL13 and TNF-alpha promoters. It contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. |
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NFAM1 Antibody Blocking Peptide(bs-2680P)-500ug
￥880
