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- bs-2808P
- 2025年10月16日
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500ug
| 产品编号 | bs-2808P |
| 英文名称 | Jak3 Antibody Blocking Peptide |
| 中文名称 | 蛋白酪氨酸激酶JAK-3封闭多肽 |
| 英文别名 | JAK 3; JAK L; JAK3 HUMAN; JAKL; Janus kinase 3 (a protein tyrosine kinase, leukocyte); Janus Kinase 3; Janus Kinase3; L JAK; Leukocyte janus kinase; LJAK; Protein tyrosine kinase leukocyte; Tyrosine protein kinase JAK3; EC 2.7.10.2. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Oncoproteins > Signal transducers Cancer > Signal transduction > Protein phosphorylation > Tyrosine kinases Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > STATs Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Signal Transduction > Protein Phosphorylation > Tyrosine Kinases Signal Transduction > Signaling Pathway > Nuclear Signaling > STATs |
| 亚基 | Interacts with STAM2 and MYO18A. Interacts with SHB. |
| 亚细胞定位 | Endomembrane system; Peripheral membrane protein. Cytoplasm. |
| 组织特异性 | In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B-form is detected in cells both of hematopoietic and epithelial origins. |
| 翻译后修饰 | Tyrosine phosphorylated in response to IL-2 and IL-4. |
| 相似性 | Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain. Contains 2 protein kinase domains. Contains 1 SH2 domain. |
| 功能 | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008] |
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Jak3 Antibody Blocking Peptide(bs-2808P)-500ug
￥880
