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- bs-3244P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-3244P |
| 英文名称 | Phospho-LAT (Tyr191) Antibody Blocking Peptide |
| 中文名称 | 磷酸化T细胞活化连接蛋白封闭多肽 |
| 英文别名 | LAT (Phospho Tyr191); LAT (Phospho Y191); p-LAT (Tyr191); p-LAT (Y191); p-LAT (Phospho Tyr191); Linker for activation of T cell 1; 36 kDa phospho tyrosine adapter protein; LAT 1; LAT1; Linker for activation of T cells; Linker for activation of T cells family member 1; p36 38; pp36; LAT_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Adaptive Immunity > T Cells > Non-CD Signal Transduction > Adapters > Transmembrane Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Ras Family |
| 亚基 | When phosphorylated, interacts directly with the PIK3R1 subunit of phosphoinositide 3-kinase and the SH2 domains of GRB2, GRAP, GRAP2, PLCG1 and PLCG2. Interacts indirectly with CBL, SOS, VAV, and LCP2. Interacts with SHB, SKAP2 and CLNK. Interacts with FCGR1A. Interacts with GRB2, PLCG1 and THEMIS upon TCR activation in thymocytes. |
| 亚细胞定位 | Cell membrane. Present in lipid rafts. |
| 组织特异性 | Expressed in thymus, T-cells, NK cells, mast cells and, at lower levels, in spleen. Present in T-cells but not B-cells (at protein level). |
| 翻译后修饰 | Phosphorylated on tyrosines by ZAP-70 upon TCR activation, or by SYK upon other immunoreceptor activation; which leads to the recruitment of multiple signaling molecules. Is one of the most prominently tyrosine-phosphorylated proteins detected following TCR engagement. May be dephosphorylated by PTPRJ. Palmitoylation of Cys-26 and Cys-29 is required for raft targeting and efficient phosphorylation. |
| 相似性 | Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family. |
| 功能 | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. |
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Phospho-LAT (Tyr191) Antibody Blocking Peptide(bs-3244P)-500ug
￥1080
