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- Bioss
- bs-20200P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-20200P |
| 英文名称 | TTBK1 Antibody Blocking Peptide |
| 中文名称 | 脑源性tau蛋白激酶封闭多肽 |
| 英文别名 | BDTK; Brain derived tau kinase; Brain-derived tau kinase; KIAA1855; Tau tubulin kinase 1; Tau-tubulin kinase 1; TTBK1; TTBK1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > Protein phosphorylation > Serine/threonine kinases Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease > Tangles & Tau Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microtubules > MT Associated Proteins > Tau |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Expressed in the brain, particularly in cortical and hippocampal neurons. Weakly expressed in spinal cord and testis. No expression in adipose tissue, bladder, cervix, colon, esophagus, heart, kidney, liver, lung, ovary, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus, thyroid or trachea. |
| 相似性 | Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family.
Contains 1 protein kinase domain. |
| 功能 | Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TTBK1 (tau tubulin kinase 1), also known as BDTK (brain-derived tau kinase), is a 1,321 amino acid protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Localized to the cytoplasm and expressed at high levels in brain and at lower levels in testis and spinal cord, TTBK1 functions as a serine/threonine kinase that can phosphorylate Tau (a protein involved in tubulin polymerization) on threonine, tyrosine and serine residues. Specifically, TTBK1 uses divalent cations, such as magnesium and manganese, to catalyze the ATP-dependent transfer of a phosphate group onto Tau, creating a phosphoprotein and ADP. Phosphorylation of Tau causes its aggregation and subsequent loss of function, suggesting an important role for TTBK1 in the control of tubulin dynamics. Two isoforms of TTBK1 are expressed due to alternative splicing events. |
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TTBK1 Antibody Blocking Peptide(bs-20200P)-500ug
￥880
