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- Bioss
- bs-13100P
- 2025年10月16日
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500ug
| 产品编号 | bs-13100P |
| 英文名称 | EPS15R Antibody Blocking Peptide |
| 中文名称 | 表皮生长因子受体底物15封闭多肽 |
| 英文别名 | epidermal growth factor receptor pathway substrate 15- ike 1; Epidermal growth factor receptor substrate 15 like 1; epidermal growth factor receptor substrate EPS15R; Eps15 related protein; eps15R;EP15R_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Protein Trafficking > Vesicle Transport > Adapters Signal Transduction > Protein Trafficking > Vesicle Transport > Coat Proteins Signal Transduction > Protein Trafficking > Vesicle Transport > Regulation |
| 亚基 | Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) (By similarity). Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2. |
| 亚细胞定位 | Cell Membrane and Nuclear. |
| 翻译后修饰 | Phosphorylated on tyrosine residues by EGFR (By similarity). |
| 相似性 | Contains 1 EF-hand domain. Contains 3 EH domains. |
| 功能 | EPS15 and EPS15R are substrates of the epidermal growth factor (EGF) receptor kinase, which are characterized by their ability to bind to the clathrin adaptor protein complex adaptor protein 2, and the presence of a protein:protein interaction domain, the EH domain. Evidence suggests that EPS15 and EPS15R are involved in endocytosis. The major difference between these two related proteins is that EPS15R is also found in the nucleus, whereas EPS15 is excluded from this compartment at steady state. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation, as miscues in RTK signaling can result in cellular transformation events that may ultimately lead to cancer. Eps15 (EGF-receptor pathway substrate 15) is an EGF receptor substrate that become become tyrosine phosphorylated subsequent to EGF stimulation. Over expression of Eps15 in NIH/3T3 cells causes cellular transformation, implying involvement of Eps15 in the regulation of cell proliferation. Eps15R (Eps15-related), also known as Eps15L1 (epidermal growth factor receptor substrate 15-like 1), is an 864 amino acid protein that contains one EF-hand domain and three EH domains. Localized to a variety of places within the cell, including the nucleus, cytoplasm and membrane-coated pits, Eps15R is thought to function as a component of clathrin-coated pits. Like Eps15, Eps15R may play an important role in receptor-mediated endocytosis. |
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EPS15R Antibody Blocking Peptide(bs-13100P)-500ug
￥880
