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- bs-3259P
- 2025年10月16日
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500ug
| 产品编号 | bs-3259P |
| 英文名称 | Phospho-MAP2 (Ser136) Antibody Blocking Peptide |
| 中文名称 | 磷酸化微管相关蛋白2封闭多肽 |
| 英文别名 | MAP2(Phospho Ser136); MAP2 (phospho S136); p-MAP2 (phospho S136); MAP2(Phospho S136); MAP2(Phospho-Ser136); p-MAP2(Phospho-Ser136); DKFZp686I2148; Dendrite specific MAP; DKFZp686I2148; MAP 2; MAP-2; MAP2; MAP2_HUMAN; MAP2A; MAP2B; MAP2C; Microtubule associated protein 2; Microtubule-associated protein 2; Mtap 2. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Dendrite marker Neuroscience > Cell Type Marker > Neuron marker > Soma marker Signal Transduction > Antibodies > map2 Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microtubules > MT Associated Proteins > MAP Stem Cells > Neural Stem Cells > Neuron Restricted Lineage |
| 亚细胞定位 | Cytoplasm, cytoskeleton (Probable). |
| 翻译后修饰 | Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). MAP2A/c is phosphorylated. Isoform MAP2c is phosphorylated by FYN at Tyr-67. |
| 相似性 | Contains 3 Tau/MAP repeats. |
| 功能 | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton. |
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Phospho-MAP2 (Ser136) Antibody Blocking Peptide(bs-3259P)-500ug
￥1080
