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- Bioss
- bs-11812P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-11812P |
| 英文名称 | CADPS Antibody Blocking Peptide |
| 中文名称 | 钙依赖分泌激活蛋白1封闭多肽 |
| 英文别名 | Cadps; CADPS1; Calcium dependent secretion activator 1; Calcium-dependent activator protein for secretion 1; Calcium-dependent secretion activator 1; Caps; CAPS-1; rCAPS; CAPS1_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Homodimer. Interacts with RASL10B. Interacts with the dopamine receptor DRD2. |
| 亚细胞定位 | Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to DCVs but not to SVs. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2. |
| 组织特异性 | Specifically expressed in neural and endocrine secretory tissues. Expressed in brain and pancreas and at low level in heart. Also expressed in fetal heart, cerebellum, cerebral cortex, medulla, occipital pole, frontal and temporal lobes, and putamen, as well as weak expression in spinal cord. |
| 相似性 | Contains 1 C2 domain. Contains 1 MHD1 (MUNC13 homology domain 1) domain. Contains 1 PH domain. |
| 功能 | CAPS1 (Ca2+-dependent activator protein for secretion) belongs to the CAPS/Cadps family which consists of two members, CAPS1 and CAPS2. The CAPS family proteins are involved in the secretion of different secretory substances in developing and postnatal brains. In addition CAPS1 regulates catecholamine release from neuroendocrine cells and is expressed predominantly in the brain. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008] |
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CADPS Antibody Blocking Peptide(bs-11812P)-500ug
￥880
