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- Bioss
- bs-11811P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-11811P |
| 英文名称 | BRWD3 Antibody Blocking Peptide |
| 中文名称 | 智力发育调节相关蛋白BRWD3封闭多肽 |
| 英文别名 | BRODL; Bromo domain containing protein disrupted in leukemia; Bromodomain and WD repeat domain containing 3; Novel WD repeat domain protein; BRWD3_HUMAN. |
| 纯化方法 | HPLC |
| 组织特异性 | Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined. |
| 翻译后修饰 | Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Contains 2 bromo domains. Contains 9 WD repeats. |
| 功能 | BRWD3 is found in most adult tissues. A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Defects in BRWD3 are the cause of mental retardation X-linked type 93. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the WD repeat protein family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis and gene regulation. BRWD3 (bromodomain and WD repeat-containing protein 3) is a 1,802 amino acid protein expressed in fetal liver and most adult tissues. Existing as five alternatively spliced isoforms, BRWD3 contains two bromo domains, nine WD repeats and is thought to play a role in transcription by modifying chromatin. Mutations in the gene encoding BRWD3 are the cause of mental retardation X-linked type 93 (MRX93), which is also known as mental retardation X-linked with macrocephaly (XLMR). MRX93 is characterized by mild intellectual disability, macrocephaly, a prominent forehead and large cupped ears. |
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BRWD3 Antibody Blocking Peptide(bs-11811P)-500ug
￥880
