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- Bioss
- bs-17092P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-17092P |
| 英文名称 | UBR4 Antibody Blocking Peptide |
| 中文名称 | E3泛素蛋白连接酶UBR4封闭多肽 |
| 英文别名 | Ubiquitin Protein Ligase E3 Component N-Recognin 4; Retinoblastoma-Associated Factor Of 600 KDa; Zinc Finger UBR1-Type Protein 1; N-Recognin-4; RBAF600; ZUBR1; P600; Retinoblastoma-Associated Factor 600-Like Protein; 600 KDa Retinoblastoma Protein-Associated Factor; E3 Ubiquitin-Protein Ligase UBR4; Zinc Finger, UBR1 Type 1; EC 6.3.2.-; KIAA0462 KIAA1307; EC 6.3.2; GC01M019074; UBR4_HUMAN; |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger Microbiology > Interspecies Interaction > Host Virus Interaction Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Focal Adhesions |
| 亚基 | Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11. |
| 亚细胞定位 | Membrane Curated; Multi-pass membrane protein; Cytoplasm; cytoskeleton; Nucleus |
| 相似性 | Belongs to the UBR4 family. |
| 功能 | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010] |
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UBR4 Antibody Blocking Peptide(bs-17092P)-500ug
￥880
