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- Bioss
- bs-20001P
- 2025年10月16日
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500ug
| 产品编号 | bs-20001P |
| 英文名称 | SIGLEC11 Antibody Blocking Peptide |
| 中文名称 | 唾液酸结合性免疫球蛋白样凝集素11封闭多肽 |
| 英文别名 | sialic acid binding Ig like lectin 11; sialic acid binding lectin 11; Siglec 11; SIG11_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Immunology > Innate Immunity > Macrophage / Inflamm. Tags & Cell Markers > Cell Type Markers > Neuroscience Markers > Glial Tags & Cell Markers > Cell Type Markers > Other Cell Types |
| 亚基 | Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation. |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 组织特异性 | Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia. |
| 翻译后修饰 | Phosphorylated on tyrosine residues. |
| 相似性 | Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. |
| 功能 | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
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SIGLEC11 Antibody Blocking Peptide(bs-20001P)-500ug
￥880
