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- Bioss
- bs-1573P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-1573P |
| 英文名称 | PUMA / BBC3 Antibody Blocking Peptide |
| 中文名称 | p53正向细胞凋亡调控因子封闭多肽 |
| 英文别名 | PUMA; bcl-2 binding component 3; BBC 3; BBC3; BCL 2 binding component 3; BCL2 binding component 3; JFY 1; JFY1; p53 up regulated modulator of apoptosis; p53 Upregulated Modulator of Apoptosis; PUMA alpha; PUMA/JFY1; BBC3_RAT. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cell Death > Apoptosis > Apoptosis Markers > Bcl 2 family Cancer > Cell Death > Apoptosis > Metabolism Cancer > Invasion/microenvironment > Apoptosis > Bcl 2 family Cell Biology > Apoptosis > Intracellular > Bcl2 Family Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers Metabolism > Types of disease > Cancer Signal Transduction > Metabolism > Mitochondrial |
| 亚基 | Interacts with BCL2, BCL2L1/BCL-XL, MCL1 and BCL2A1. |
| 亚细胞定位 | Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. |
| 相似性 | Belongs to the Bcl-2 family. |
| 功能 | Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Essential for ER stress-induced cell death. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] |
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PUMA / BBC3 Antibody Blocking Peptide(bs-1573P)-500ug
￥880
