EFTUD2 Antibody Blocking Peptide(bs-13061P)-500ug

EFTUD2 Antibody Blocking Pepti

de(bs-13061P)-500ug
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  • bs-13061P
  • 2025年10月16日
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      500ug

    产品编号bs-13061P
    英文名称EFTUD2 Antibody Blocking Peptide
    中文名称延伸因子结合蛋白EFTUD2封闭多肽
    英文别名116 kDa; 116 kDa U5 small nuclear ribonucleoprotein component; EFTUD2; Elongation factor Tu GTP binding domain containing 2; Elongation factor Tu GTP-binding domain-containing protein 2; hSNU114; MFDM; Snrp116; Snu114; SNU114 homolog; U5 116KD; U5 small nuclear ribonucleoprotein component; U5 snRNP specific protein, 116 kD; U5 snRNP specific protein, 116 kDa; U5 snRNP-specific protein; U5-116 kDa; U5S1_HUMAN.
    纯化方法HPLC
    研究领域

    Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > Splicing

    亚基Identified in the spliceosome C complex. Interacts with ERBB4 and PRPF8.
    亚细胞定位Nucleus.
    翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    相似性Belongs to the GTP-binding elongation factor family.
    EF-G/EF-2 subfamily.
    功能Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.
    保存条件Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Spliceosomes are multi-protein complexes that are composed of snRNPs (small nuclear ribonucleoproteins) and a variety of associated protein factors, all of which work in concert to regulate the splicing of pre-mRNA. Snrp116, also known as EFTUD2 (elongation factor Tu GTP binding domain containing 2) or Snu114, is a 972 amino acid protein that localizes to the nucleus and belongs to the GTP-binding elongation factor family. Existing as a component of the multi-protein U5 snRNP spliceosome complex, Snrp116 plays an important role in pre-mRNA splicing, as well as in the recycling of spliceosomal snRNPs. The gene encoding Snrp116 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.

     

     

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