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- Bioss
- bs-15588P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-15588P |
| 英文名称 | OAS2 Antibody Blocking Peptide |
| 中文名称 | 2'-5'-寡腺苷酸合成酶2封闭多肽 |
| 英文别名 | (2-5'')oligo(A) synthase 2; (2-5')oligo(A) synthetase 2; 2''-5''-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2-5A synthase 2; 2-5A synthetase 2; MGC78578; OAS2; OAS2_HUMAN; p69 OAS / p71 OAS; p69OAS / p71OAS. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing Immunology > Innate Immunity > Cytokines > Interferons Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus |
| 亚基 | Homodimer. |
| 亚细胞定位 | Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Nucleus. Microsome. Endoplasmic reticulum.Note=Associated with different subcellular fractions such asmitochondrial, nuclear, and rough/smooth microsomal fractions. |
| 翻译后修饰 | Myristoylation is not essential for its activity. Glycosylated. Glycosylation is essential for its activity. |
| 相似性 | Belongs to the 2-5A synthase family. |
| 功能 | Interferon-induced, dsRNA-activated antiviral enzymewhich plays a critical role in cellular innate antiviral response.In addition, it may also play a role in other cellular processessuch as apoptosis, cell growth, differentiation and generegulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates(2-5A) from ATP which then bind to the inactive monomeric form ofribonuclease L (RNase L) leading to its dimerization and subsequentactivation. Activation of RNase L leads to degradation of cellularas well as viral RNA, resulting in the inhibition of proteinsynthesis, thus terminating viral replication. Can mediate theantiviral effect via the classical RNase L-dependent pathway or analternative antiviral pathway independent of RNase L.[CATALYTIC ACTIVITY] 3 ATP = pppA2'p5'A2'p5'A + 2 diphosphate. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. |
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OAS2 Antibody Blocking Peptide(bs-15588P)-500ug
￥880
