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- Bioss
- bs-13046P
- 2025年10月16日
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500ug
| 产品编号 | bs-13046P |
| 英文名称 | SLC1A6 Antibody Blocking Peptide |
| 中文名称 | 胶质细胞谷氨酸运载蛋白4封闭多肽 |
| 英文别名 | Excitatory amino acid transporter 4; SLC1A6; High affinity neuronal glutamate transporter; MGC33092; MGC43671; Sodium dependent glutamate/aspartate transporter; Solute carrier family 1 (high affinity aspartate/glutamate transporter) member 6; Solute carrier family 1 member 6; |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmitter > Amino Acids > Aspartate Neuroscience > Neurotransmitter > Amino Acids > Glutamate Neuroscience > Neurotransmitter > Transporters > Glutamate |
| 亚细胞定位 | Membrane; multi-pass membrane protein. |
| 组织特异性 | Brain. Expressed densely and selectively incell bodies of Purkinje cells. |
| 相似性 | Belongs to the sodium:dicarboxylate (SDF) symporter(TC 2.A.23) family. SLC1A6 subfamily. |
| 功能 | EAAT4 is expressed predominantly in the cerebellum (Purkinje cells) and weakly in the forebrain, where it transports L-glutamate, L-aspartate and D-aspartate, acting as a symport by cotransporting sodium. EAAT4 may function as a combined transporter and inhibitory glutamate receptor and also functions as an anion-selective ion channel. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Excitatory Amino Acid Transporters (EAATs) are membrane-bound proteins that are localized in glial cells and pre-synaptic glutamatergic nerve endings. EAATs transport the excitatory neurotransmitters L-glutamate and D-aspartate, a process that is essential for terminating the postsynaptic action of glutamate. The re-uptake of amino acid neurotransmitters by EAAT proteins has been shown to protect neurons from excitotoxicity, which is caused by the accumulation of amino acid neurotransmitters. EAAT4 is an aspartate/glutamate transporter that is expressed predominantly in the cerebellum. The transport activity encoded by EAAT4 has high apparent affinity for L-aspartate and L-glutamate, and has a pharmacologic profile consistent with previously described cerebellar transport activities. EAAT5 is a glutamate transporter coupled to a chloride conductance which is expressed primarily in retina. Although EAAT5 shares the structural homologies of the EAAT family, a novel feature of the EAAT5 sequence is a carboxy-terminal motif previously identified in N-ethyl-D-aspartate receptors and potassium channels and shown to confer interactions with a family of synaptic proteins that promote ion channel clustering. |
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SLC1A6 Antibody Blocking Peptide(bs-13046P)-500ug
￥880
