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- Bioss
- bs-1556P
- 2025年10月16日
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500ug
| 产品编号 | bs-1556P |
| 英文名称 | PFN1 Antibody Blocking Peptide |
| 中文名称 | 前纤维蛋白1封闭多肽 |
| 英文别名 | Actin binding protein; PFN 1; Pfn; PFN1; Profilin I; Profilin1; ProfilinI; PROF1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Oncoproteins/suppressors > Tumor suppressors Cell Biology > Cell Cycle > Cell differentiation Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Assembly Tags & Cell Markers > Subcellular Markers > Cytoskeleton > Actin |
| 亚基 | Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with VASP. Interacts with HTT. |
| 亚细胞定位 | Cytoplasm, cytoskeleton. |
| 组织特异性 | Expressed in epididymis (at protein level). |
| 翻译后修饰 | Phosphorylation at Ser-138 reduces its affinity for G-actin and blocks its interaction with HTT, reducing its ability to inhibit androgen receptor (AR) and HTT aggregation. |
| 相似性 | Belongs to the profilin family. |
| 功能 | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Profilin 1 is a ubiquitous actin monomer-binding protein involved in actin polymerization in response to extracellular signals. Three profilin genes have been identified: profilin 1, 2, and 3. Profilin 1 is the most ubiquitous and abundant, and is highly expressed throughout development and adulthood inmost tissues including brain. Profilin 2 is the neuronal specific isoform and profilin 3 is a testis specific isoform. Profilins of eukaryotic cells are small (12-15 kDa) cytoplasmic proteins that bind to actin monomers, polyphosphoinositides and polymers of L-proline. Profilins were shown to be important for normal cell proliferation, differentiation and motility. Deletion of profilin 1 gene leads to an embryonic lethal phenotype. |
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PFN1 Antibody Blocking Peptide(bs-1556P)-500ug
￥880
