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- Bioss
- bs-11768P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11768P |
| 英文名称 | TDRD3 Antibody Blocking Peptide |
| 中文名称 | Tudor结构域蛋白TDRD3封闭多肽 |
| 英文别名 | TDRD 3; tdrd3; TDRD3_HUMAN; Tudor domain containing 3; Tudor domain containing protein 3; Tudor domain-containing protein 3; 4732418C03Rik; 6720468N18; FLJ21007; OTTHUMP00000018485. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing Neuroscience > Neurology process > Neurodegenerative disease |
| 亚基 | Component of mRNA stress granules. Interacts with FMR1, FXR1, FXR2, EWSR1, FUS, SERBP1, EEF1A1 and DDX3X or DDX3Y, and with the small nuclear ribonucleoprotein-associated proteins SNRPB and SNRPN. Interacts with 'Lys-48'-linked tetra-ubiquitin, but not with monoubiquitin or 'Lys-63'-linked ubiquitin chains. |
| 亚细胞定位 | Cytoplasm. Nucleus. Predominantly cytoplasmic. Associated with actively translating polyribosomes and with mRNA stress granules. |
| 组织特异性 | Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| 相似性 | Contains 1 Tudor domain. Contains 1 UBA domain. |
| 功能 | Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Tudor domain containing 3 is a 651 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one UBA domain and one tudor domain. Expressed in lung, brain, heart, liver, placenta, kidney, pancreas and skeletal muscle, TDRD3 exists as a component of mRNA stress granules and is thought to play a role in the translation of target mRNAs, as well as in the assembly and disassembly of stress granules. Multiple isoforms of TDRD3 exist due to alternative splicing events. The gene encoding TDRD3 maps to human chromosome 13, which houses over 400 genes, such as BRCA2 and RB1, and comprises nearly 4% of the human genome. Trisomy 13, also known as Patau syndrome, is deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections. |
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TDRD3 Antibody Blocking Peptide(bs-11768P)-500ug
￥880
