- ￥880
- Bioss
- bs-11767P
- 2025年10月16日
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- 详细信息
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- 规格：
500ug
| 产品编号 | bs-11767P |
| 英文名称 | TBCE Antibody Blocking Peptide |
| 中文名称 | 微管蛋白特定伴侣蛋白E封闭多肽 |
| 英文别名 | HRD; KCS; KCS1; Pac2; tbce; TBCE_HUMAN; Tubulin specific chaperone e; Tubulin-folding cofactor E; Tubulin-specific chaperone E. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurology process > Neurodegenerative disease Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microtubules > Tubulin Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚基 | Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. Cofactors B and E can form a heterodimer which binds to alpha-tubulin and enhances their ability to dissociate tubulin heterodimers. |
| 亚细胞定位 | Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). |
| 相似性 | Belongs to the TBCE family. Contains 1 CAP-Gly domain. Contains 7 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. |
| 功能 | Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Microtubules, the primary component of the cytoskeletal network, are highly dynamic structures composed of Alpha/Beta Tubulin heterodimers. Biosynthesis of functional microtubules involve the participation of several chaperones, termed Tubulin folding cofactors A (TBCA), D (TBCD), E (TBCE) and C (TBCC), that act on folding intermediates downstream of the cytosolic chaperon, alternatively named TCP. TBCE (tubulin folding cofactor E), also known as HRD, KCS, KCS1 or pac2, is a 527 amino acid cytoplasmic protein containing one CAP-Gly domain and seven LRR (leucine-rich) repeats. TBCE is involved in the second step of the Tubulin folding pathway and is implicated in the maintenance of the neuronal microtubule network. TBCE associates with microtubules and proteasomes, and protects against misfolded protein stress. Mutations in the gene encoding TBCE are the cause of hypoparathyroidism-retardation-dysmorphism syndrome and Kenny-Caffey syndrome type 1. |
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TBCE Antibody Blocking Peptide(bs-11767P)-500ug
￥880
