- ￥880
- Bioss
- bs-13037P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-13037P |
| 英文名称 | Dymeclin Antibody Blocking Peptide |
| 中文名称 | 迪格弗-梅尔基奥尔-克劳森综合征相关蛋白封闭多肽 |
| 英文别名 | DMC; Dyggve-Melchior-Clausen syndrome protein; DYM; FLJ20071; FLJ90130; SMC; DYM_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Developmental Biology > Organogenesis > Nervous system development Developmental Biology > Organogenesis > Skeletal development > Bone Signal Transduction > Protein Trafficking > Golgi Proteins |
| 亚基 | Interacts with GOLM1 and PPIB. |
| 亚细胞定位 | Cytoplasmic and Golgi Apparatus |
| 组织特异性 | Expressed in most embryo-fetal and adult tissues. Abundant in primary chondrocytes, osteoblasts, cerebellum, kidney, lung, stomach, heart, pancreas and fetal brain. Very low or no expression in the spleen, thymus, esophagus, bladder and thyroid gland. |
| 翻译后修饰 | Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment. |
| 相似性 | Belongs to the dymeclin family. |
| 功能 | Necessary for correct organization of Golgi apparatus. Involved in bone development. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Dyggve-Melchior-Clausen syndrome (DMC), a rare autosomal recessive disorder, is characterized by microcephaly, short trunk dwarfism and sometime psychomotor retardation. Cutaneous cells of affected individuals show dilated rough endoplasmic reticulum and enlarged vacuoles. The Dyggve-Melchior-Clausen syndrome protein, also designated dymeclin, may play a role in proteoglycan metabolism and intracellular protein digestion. It is a widely expressed multi-pass membrane protein, detected primarily in chondrocytes and fetal brain tissue. Defects in dymeclin are also the cause of Smith-McCort dysplasis syndrome (SMC), which has characteristics identical to those of Dyggve-Melchior-Clausen syndrome. |
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Dymeclin Antibody Blocking Peptide(bs-13037P)-500ug
￥880
