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- bs-14265P
- 2025年10月16日
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500ug
| 产品编号 | bs-14265P |
| 英文名称 | DTX1 Antibody Blocking Peptide |
| 中文名称 | E3泛素蛋白连接酶封闭多肽DTX1封闭多肽 |
| 英文别名 | Deltex homolog 1 (Drosophila); Deltex protein 1; Deltex-1; Deltex1; Dtx1; E3 ubiquitin protein ligase DTX1; FXI-T1; Fxit 1; Fxit1; DTX1_HUMAN; hDTX1; hDx 1; mDTX1; Protein deltex 1. |
| 纯化方法 | HPLC |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin E3 Enzymes > Other E3 Ligases Epigenetics and Nuclear Signaling > Transcription > Other factors Neuroscience > Neurology process > Notch Pathway |
| 亚基 | Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1 via its N-terminus region and EIF3F, the interaction is required for NOTCH1 deubiquitination. Interacts with EP300. Forms a heterodimer with BBAP; the heterodimerization leading to an increase of in vitro ubiquitin ligase activity. Interacts with ITCH. |
| 亚细胞定位 | Cytoplasm and Nucleus. Note: Predominantly cytoplasmic, partially nuclear. |
| 组织特异性 | Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells. |
| 翻译后修饰 | Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. |
| 相似性 | Belongs to the Deltex family. Contains 1 RING-type zinc finger. Contains 2 WWE domains. |
| 功能 | Deltex is a RING finger ubiquitin ligase which is conserved from Drosophila to Humans and is a regulator of Notch signaling pathway. Deltex regulates both B-cell lineage and splenic marginal-zone B-cell commitment. Deltex is implicated in neurogenesis, lymphogenesis and myogenesis as well as marginal zone B cell differentiation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008] |
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DTX1 Antibody Blocking Peptide(bs-14265P)-500ug
￥880
