- ￥880
- Bioss
- bs-13016P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-13016P |
| 英文名称 | POLH Antibody Blocking Peptide |
| 中文名称 | DNA聚合酶η封闭多肽 |
| 英文别名 | DNA polymerase eta; FLJ16395; FLJ21978; POLH; POLH_HUMAN; polymerase DNA directed eta; RAD30; RAD30 homolog A; RAD30A; Xeroderma pigmentosum variant type protein; XP V; XPV. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis > Translesion Synthesis |
| 亚基 | Interacts with REV1 (By similarity). Interacts with monoubiquitinated PCNA, but not unmodified PCNA. Interacts with POLI. |
| 亚细胞定位 | Nucleus. Accumulates at replication forks after DNA damage. |
| 相似性 | Belongs to the DNA polymerase type-Y family. Contains 1 umuC domain. |
| 功能 | DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. May play a role in hypermutation at immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. Targets POLI to replication foci. |
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POLH Antibody Blocking Peptide(bs-13016P)-500ug
￥880
