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- Bioss
- bs-11721P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11721P |
| 英文名称 | CIC Antibody Blocking Peptide |
| 中文名称 | Capicua蛋白封闭多肽 |
| 英文别名 | Capicua homolog (Drosophila); Cic; CIC; KIAA0306; Protein capicua homolog; CIC_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Other factors Neuroscience > Neurology process > Neurodegenerative disease |
| 亚基 | Interacts with ATXN1 and ATXN1L |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in fetal brain. |
| 相似性 | Contains 1 HMG box DNA-binding domain. |
| 功能 | Transcriptional repressor which may play a role in development of the central nervous system (CNS). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Capicua is the mammalian ortholog of the drosophilia Cic gene and is part of the HMG-box protein superfamily. Expressed primarily in the fetal brain, Capicua functions as a transciptional repressor and is involved in the development of the nervous system through interaction with the ATXN1 protein. When ATXN1 assembles into stable complexes, it directly binds Capicua, thereby mediating both the activity and expression of Capicua. When Capicua is active, it is able to interact with other developmental proteins to restrict the growth of granule cells and regulate normal neuronal development. Disruptions in the the association of Capicua with proteins such as ATXN1 are thought to cause medulloblastoma, the most common form of perdiatric brain tumor arising from irregular growth of granule cells. |
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CIC Antibody Blocking Peptide(bs-11721P)-500ug
￥880
