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- bs-2957P
- 2025年10月16日
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500ug
| 产品编号 | bs-2957P |
| 英文名称 | SCNN1A Antibody Blocking Peptide |
| 中文名称 | 钠通道蛋白α 封闭多肽 |
| 英文别名 | SCNNA_HUMAN; Amiloride-sensitive sodium channel subunit alpha; Alpha-NaCH; Epithelial Na(+) channel subunit alpha (Alpha-ENaC; ENaCA); Nonvoltage-gated sodium channel 1 subunit alpha; SCNEA; SCNN1; sodium channel epithelial 1 subunit alpha; BESC2; ENaCa; LIDLS3; PHA1B1; ENaCalpha; |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Neurotransmission > Receptors / Channels > Sodium Channels Signal Transduction > Metabolism > Plasma Membrane > Channels |
| 亚基 | Probable heterotrimer containing one alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Interacts with the full length immature form of PCSK9 (pro-PCSK9). |
| 亚细胞定位 | Apical cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Highly expressed in kidney and lung. Detected at intermediate levels in pancreas and liver, and at low levels in heart and placenta. Isoform 1 and isoform 2 predominate in all tissues. Expression of isoform 3, isoform 4 and isoform 5 is very low or not detectable, except in lung and heart. |
| 翻译后修饰 | Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation (By similarity). ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. |
| 相似性 | Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1A subfamily. |
| 功能 | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
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SCNN1A Antibody Blocking Peptide(bs-2957P)-500ug
￥880
