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- bs-2936P
- 2025年10月16日
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500ug
| 产品编号 | bs-2936P |
| 英文名称 | ARHG7 Antibody Blocking Peptide |
| 中文名称 | p21活化蛋白激酶ARHG7封闭多肽 |
| 英文别名 | ARHG7_HUMAN; ARHG7; ARHGEF 7; ARHGEF7; Beta pix; betaPix; betaPix-b; betaPix-c; Cool; COOL1; P50 antibody P50BP; P85; P85COOL1; P85SPR; PAK interacting exchange factor beta; PAK3; Pak3bp; PAK3BP; PIX; PIXB; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor (GEF) 7b; Rho guanine nucleotide exchange factor (GEF7); Rho guanine nucleotide exchange factor 7; SH3 domain containing proline rich protein; Nbla10314; KIAA0142. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction > G protein signaling > Small G proteins Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Crosslinking Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins |
| 亚基 | Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with ITCH (By similarity). Interacts with unphosphorylated PAK1. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. |
| 翻译后修饰 | Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1. |
| 相似性 | Contains 1 CH (calponin-homology) domain. Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 SH3 domain. |
| 功能 | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. May function in cell migration. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ARHGEF7 is a p21-activated protein kinase (Pak)-interacting exchange factor that has been identified as a putative guanine nucleotide exchange factor (GEF) for Rac/Cdc42. It is expressed ubiquitously in all the tissue examined and other isoforms are expressed mainly in the central nervous system. Regulated phosphorylation of ARHGEF7 is necessary to maintain the balance between normal signalling by EGFR and Src versus aberrant growth and transformation.Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined. |
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ARHG7 Antibody Blocking Peptide(bs-2936P)-500ug
￥880
