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- 2025年10月16日
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500ug
| 产品编号 | bs-3610P |
| 英文名称 | CAV3 Antibody Blocking Peptide |
| 中文名称 | 细胞质膜微囊蛋白-3封闭多肽 |
| 英文别名 | CAV 3; CAV3; Caveolin3; Caveolin 3; LGMD1C; M caveolin; VIP 21; VIP21; AI385751; Cav-3; caveolin-3; M-cav; M-caveolin; CAV3_MOUSE. |
| 纯化方法 | HPLC |
| 研究领域 | Cardiovascular > Heart > Cardiac metabolism Cardiovascular > Heart > Hypertrophy Developmental Biology > Organogenesis > Skeletal development > Muscle Signal Transduction > Metabolism > Plasma Membrane > Channels Signal Transduction > Metabolism > Vitamins / Minerals Signal Transduction > Protein Trafficking > Golgi Proteins |
| 亚基 | Homooligomer (By similarity). Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD (By similarity). Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling. |
| 亚细胞定位 | Golgi apparatus membrane; Peripheral membrane protein (By similarity). Cell membrane; Peripheral membrane protein (By similarity). Membrane, caveola; Peripheral membrane protein (By similarity). Note=Potential hairpin-like structure in the membrane. Membrane protein of caveolae (By similarity). |
| 组织特异性 | Expressed predominantly in muscle. |
| 翻译后修饰 | Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2 (By similarity). |
| 相似性 | Belongs to the caveolin family. |
| 功能 | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Caveolae are specialized domains of the plasma membrane that are implicated in the sequestration of a variety of lipid and protein molecules. It has been suggested that these important cellular organelles have a pivotal role in such diverse biochemical processes as lipid metabolism, growth regulation, signal transduction, and apoptosis. Caveolin interacts with and regulates heterotrimeric G-proteins. Currently, there are three members of the caveolin multigene family which are integral membrane proteins that comprise the major structural component of the caveolar membrane in vivo. Caveolin-2 protein is abundantly expressed in fibroblasts and differentiated adipocytes, smooth and skeletal muscle, and endothelial cells. The expression of caveolin-1 is similar to that of caveolin-2 while caveolin-3 expression appears to be limited to muscle tissue types. |
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文献和实验or from the literature are missing. In this article, processing parameters for DNA, peptide, antibody, and carbohydrate microarrays are outlined. The applicability of the model experiments is demonstrated and described in detail on the example of short oligonucleotides.
Synthesis and Probing of Membrane-bound Peptide Arrays
the stringency of the blocking conditions and make sure that the primary binding partner and detection reagent (e.g., antibody) are of high purity and are used in the highest possible dilution. Stage
Mapping Protein‐Protein Interactions with Phage‐Displayed Combinatorial Peptide Libraries
. Fack, F., Deroo, S., Kreis, S., and Muller, C.P. 2000. Heteroduplex mobility assay (HMA) pre‐screening: An improved strategy for the rapid identification of inserts selected from phage‐displayed peptide
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