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- Bioss
- bs-11682P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11682P |
| 英文名称 | SPPL2B Antibody Blocking Peptide |
| 中文名称 | 膜内蛋白酶4封闭多肽 |
| 英文别名 | SPPL2B; IMP4; Signal peptide peptidase-like 2B; Intramembrane protease 4; Protein SPP-like 2B; SPPL2B; SPP2B_HUMAN. |
| 纯化方法 | HPLC |
| 亚基 | Monomer. Homodimer. Interacts with ITM2B and TNF. |
| 亚细胞定位 | Membrane; multi-pass membrane protein of endosomes/lysosomes. |
| 组织特异性 | Expressed predominantly in adrenal cortex and mammary gland. |
| 翻译后修饰 | Glycosylated. |
| 相似性 | Belongs to the peptidase A22B family. Contains 1 PA (protease associated) domain. |
| 功能 | The SPPLs are a group of aspartic proteases that are responsible for proteolysis of type II membrane-anchored signalling factors. SPPL2b, unlike other SPPL family members is found in endosomes/lysosomes, and not the endoplasmic reticulum, and has a role in catalysing intramembrane cleavage of tumour necrosis factor alpha (TNFalpha). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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SPPL2B Antibody Blocking Peptide(bs-11682P)-500ug
￥880
