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- bs-2971P
- 2025年10月16日
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500ug
| 产品编号 | bs-2971P |
| 英文名称 | STK39 Antibody Blocking Peptide |
| 中文名称 | 丝氨酸/苏氨酸蛋白激酶39封闭多肽 |
| 英文别名 | PASK; Proline alanine rich STE20 related kinase; Serine threonine kinase 39 (STE20/SPS1 homolog yeast); Serine threonine kinase 39; Serine/threonine protein kinase 39; Serine/threonine-protein kinase 39; Small intestine SPAK like kinase; SPAK; Ste 20 related kinase; Ste-20-related kinase; Ste20 like protein kinase; STE20/SPS1 homolog; STE20/SPS1 related proline alanine rich protein kinase; STE20/SPS1-related proline-alanine-rich protein kinase; STK 39; Stk39; STK39_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Metabolism > Plasma Membrane > Channels Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases |
| 亚基 | The phosphorylated form forms a complex with WNK2 (By similarity). |
| 亚细胞定位 | Cytoplasm. Nucleus. Nucleus when caspase-cleaved. |
| 组织特异性 | Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis. |
| 翻译后修饰 | Phosphorylated at Ser-309 by PRKCQ. |
| 相似性 | Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family. STE20 subfamily. Contains 1 protein kinase domain. |
| 功能 | May act as a mediator of stress-activated signals. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. SPAK, also known as STK39 (serine threonine kinase 39), DCHT or PASK, is a 547 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one protein kinase domain. Expressed predominately in pancreas, brain, heart, lung, liver and testis, SPAK functions as a Ser/Thr protein kinase that catalyzes the ATP-dependent phosphorylation of target proteins and is thought to be involved in mediating stress-activated signals. The gene encoding SPAK maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. |
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STK39 Antibody Blocking Peptide(bs-2971P)-500ug
￥880
