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- bs-12987P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-12987P |
| 英文名称 | DCPS Antibody Blocking Peptide |
| 中文名称 | 清道夫脱帽酶/热休克蛋白1封闭多肽 |
| 英文别名 | 1700001E16Rik; AA408441; DCPS; DCPS_HUMAN; DCS 1; DCS-1; DCS1; Decapping enzyme scavenger; heat shock-like protein 1; Hint 5; Hint related 7meGMP directed hydrolase; HINT-5; Hint-related 7meGMP-directed hydrolase; HINT5; Histidine triad protein member 5; homolog of C. elegans 7meGMP-directed hydrolase dcs-1; HSL1; HSPC015; m7GpppX diphosphatase; MGC124934; mRNA decapping enzyme; OTTMUSP00000042220; Scavenger mRNA decapping enzyme DcpS; Scavenger mRNA-decapping enzyme DcpS. |
| 纯化方法 | HPLC |
| 亚基 | Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1. |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Detected in liver, brain, kidney, testis and prostate. |
| 相似性 | Belongs to the HIT family. |
| 功能 | Necessary for the complete degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA fragments shorter than 10 nucleotides that are produced by 3'->5' exosome-mediated mRNA decay. Releases m7GMP. Can also degrade m7GDP to m7GMP. Has no activity towards mRNA molecules longer than 25 nucleotides. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Eukaryotic cells primarily utilize exoribonucleases and decapping enzymes to degrade their mRNA. DcpS is a scavenger pyrophosphatase that hydrolyzes the residual cap structure following 3' to 5' decay of an mRNA. Following mRNA degradation DcpS releases N-7 methyl guanosine monophosphate and 5'-diphosphate terminated cap or mRNA products. The central histidine within the DcpS HIT motif is critical for decapping activity and defines the HIT motif as a new mRNA decapping domain, making DcpS the first member of the HIT family of proteins with a defined biological function. HIT proteins are homodimeric and contain two conserved 100-amino-acid HIT fold domains with independent active sites that are each sufficient to bind and hydrolyze cognate substrates. |
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DCPS Antibody Blocking Peptide(bs-12987P)-500ug
￥880
