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- Bioss
- bs-2923P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-2923P |
| 英文名称 | SRPK1 Antibody Blocking Peptide |
| 中文名称 | 丝氨酸/苏氨酸蛋白激酶SRPK1封闭多肽 |
| 英文别名 | Serine/arginine rich protein specific kinase 1; Serine/arginine-rich protein-specific kinase 1; Serine/threonine protein kinase SRPK1; Serine/threonine-protein kinase SRPK1; SFRS protein kinase 1; SR protein kinase 1; SR protein specific kinase 1; SR-protein-specific kinase 1; SRPK1; SRPK1_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > Splicing |
| 亚基 | Present in a seven component complex, the toposome, which separates entangled circular chromatin DNA during chromosome segregation. Interacts with HHV-1 ICP27 protein. |
| 亚细胞定位 | Cytoplasm. Nucleus. |
| 组织特异性 | Isoform 2 is predominantly expressed in the testis but is also present at lower levels in heart, ovary, small intestine, liver, kidney, pancreas and skeletal muscle. Isoform 1 is only seen in the testis, at lower levels than isoform 2. |
| 相似性 | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Contains 1 protein kinase domain. |
| 功能 | Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids. |
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SRPK1 Antibody Blocking Peptide(bs-2923P)-500ug
￥880
