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- Bioss
- bs-2885P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-2885P |
| 英文名称 | Gab2 Antibody Blocking Peptide |
| 中文名称 | 接头蛋白Gab 2封闭多肽 |
| 英文别名 | GAB 2; Gab2; Grb 2 associated binder 2; GRB 2 associated binding protein 2; Grb2 associated binder 2; GRB2 associated binder 2 pp100; GRB2 associated binding protein 2; Growth factor receptor bound protein 2 associated protein 2; KIAA0571; p97; PH domain containing adaptor molecule p97; pp100; Alternative namesGRB2 associated binder 2 pp100. |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Signal transduction Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease Signal Transduction > Adapters > Cytoplasmic |
| 亚基 | Interacts with SHC1; may mediate interaction with receptors. Interacts with SYK. Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts (phosphorylated) with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling. Interacts with HCK. |
| 亚细胞定位 | Cytoplasm. Cell membrane. |
| 翻译后修饰 | Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. Dephosphorylated by PTPN11. |
| 相似性 | Belongs to the GAB family. Contains 1 PH domain. |
| 功能 | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009] |
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Gab2 Antibody Blocking Peptide(bs-2885P)-500ug
￥880
