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- Bioss
- bs-21425P
- 2025年10月16日
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- 技术资料
- 规格：
500ug
| 产品编号 | bs-21425P |
| 英文名称 | BRSK2 Antibody Blocking Peptide |
| 中文名称 | 脑蛋白丝氨酸/苏氨酸激酶29封闭多肽 |
| 英文别名 | BR serine/threonine kinase 2; BR serine/threonine-protein kinase 2; Brain selective kinase 2; Brain specific serine/threonine protein kinase 2; Brsk2; BRSK2_HUMAN; C11orf7; PEN11B; Protein kinase SAD1B; SAD1; Serine/threonine kinase 29; Serine/threonine protein kinase BRSK2; Serine/threonine-protein kinase 29; Serine/threonine-protein kinase SAD-A; STK29; SADA. |
| 纯化方法 | HPLC |
| 亚细胞定位 | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. Contains 1 protein kinase domain. |
| 翻译后修饰 | Phosphorylated at Thr-174 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-174 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-174 by PP2C. May be phosphorylated at Thr-260 by PKA. However, phosphorylation at Thr-260 by PKA was not comfirmed later (PubMed:18339622). |
| 相似性 | Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Contains 1 protein kinase domain. Contains 1 UBA domain. |
| 功能 | Required for the polarization of forebrain neurons which endows axons and dendrites with distinct properties, possibly by locally regulating phosphorylation of microtubule-associated proteins. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. BRSK2 (BR serine/threonine kinase 2), also known as SAD1, STK29 or PEN11B, is a 736 amino acid protein that contains one protein kinase domain and is preferentially expressed in brain and testis. One of several members of the Ser/Thr protein kinase family, BRSK2 uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be involved in microtubule assembly, neuronal polarization and synaptic development. Additionally, BRSK2 may function as an autoantigen involved in small-cell lung cancer-associated limbic encephalitis. Five isoforms of BRSK2 exist due to alternative splicing events. |
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BRSK2 Antibody Blocking Peptide(bs-21425P)-500ug
￥880
