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- Bioss
- bs-1407P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-1407P |
| 英文名称 | ARNT Antibody Blocking Peptide |
| 中文名称 | 缺氧诱导因子1β/HIF-1β封闭多肽 |
| 英文别名 | HIF1 beta; ARNT1; ARNT; HIF 1 beta; HIF-1 Beta; ARNT protein; Aryl Hydrocarbon Receptor Nuclear Translocator ; Dioxin Receptor; Dioxin receptor nuclear translocator; Drnt; HIF 1 beta;HIF 1beta; HIF1B; HIF1beta; Hypoxia Inducible Factor 1; Hypoxia inducible factor 1 beta; Tango; ARNT_HUMAN; Class E basic helix-loop-helix protein 2; bHLHe2; Hypoxia-inducible factor 1-beta; HIF-1-beta; HIF1-beta; HIF-1 β; HIF1-β; HIF 1-β; HIF-1-β; HIF 1 β; HIF1β; HIF1 β; HIF1-β; HIF 1β. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Cancer > Invasion/microenvironment > Hypoxia > HIF Cardiovascular > Hypoxia > HIF Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > HIF Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism Metabolism > Pathways and Processes > Metabolism processes > Hypoxia |
| 亚基 | Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with AHR, AHRR, HIF1A and EPAS1/HIF2A as well as with other bHLH proteins. Interacts with TACC3 (By similarity). Interacts with NOCA7. Heterodimer with HIF1A. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Contains 1 bHLH (basic helix-loop-helix) domain.
Contains 1 PAC (PAS-associated C-terminal) domain. Contains 2 PAS (PER-ARNT-SIM) domains. |
| 功能 | Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 背景资料 | This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
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ARNT Antibody Blocking Peptide(bs-1407P)-500ug
￥880
