- ￥880
- Bioss
- bs-15445P
- 2025年10月16日
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500ug
| 产品编号 | bs-15445P |
| 英文名称 | HERC5 Antibody Blocking Peptide |
| 中文名称 | HECT E3泛素链接酶封闭多肽 |
| 英文别名 | CEB1; CEBP1; Cyclin E binding protein 1; Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT domain and RCC1 like domain containing protein 5; HECT domain and RCC1-like domain-containing protein 5; Hect domain and RLD 5; HECT E3 ubiquitin ligase; HERC5; HERC5_HUMAN; Herc6. |
| 纯化方法 | HPLC |
| 亚基 | Binds to CCNA1, CCNB1, CCND1 and CCNE1. Interacts with UBE2L6. Interacts with IRF3, this interaction is marginal in resting cells but enhanced upon viral infection. |
| 亚细胞定位 | Cytoplasm, perinuclear region. Note=Associated with the polyribosomes, probably via the 60S subunit. |
| 组织特异性 | Expressed in testis and to a lesser degree in brain, ovary and placenta. Found in most tissues at low levels. |
| 翻译后修饰 | ISGylated (Probable). |
| 相似性 | Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 5 RCC1 repeats. |
| 功能 | Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Makes part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | HECT E3 ubiquitin ligase is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4. |
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HERC5 Antibody Blocking Peptide(bs-15445P)-500ug
￥880
