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- bs-11623P
- 2025年10月16日
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- 详细信息
- 技术资料
- 规格：
500ug
| 产品编号 | bs-11623P |
| 英文名称 | PIRT Antibody Blocking Peptide |
| 中文名称 | 磷酸肌醇相互作用蛋白封闭多肽 |
| 英文别名 | hCG_1776018; Phosphoinositide interacting regulator of transient receptor potential channels ; Phosphoinositide-interacting protein; Pirt; PIRT_HUMAN. |
| 纯化方法 | HPLC |
| 研究领域 | Neuroscience > Sensory System > Somatosensory system > Nociception Neuroscience > Sensory System > Taste system |
| 亚基 | Interacts with TRPV1 |
| 亚细胞定位 | Membrane; Multi-pass membrane protein |
| 功能 | Regulatory subunit of TRPV1, a molecular sensor of noxious heat and capsaicin. Positively regulates TRPV1 channel activity via phosphatidylinositol-4,5-bisphosphate (PIP2). Binds various phosphoinositide, including phosphatidylinositol-4,5-bisphosphate (PIP2), but not phosphatidylinositol (PI). |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | PIRT is a 137 amino acid multi-pass membrane protein. Highly conserved among vertebrates, PIRT consists of two transmembrane domains and one putative C-terminal phosphoinositide-binding domain. Although PIRT is expressed in peripheral nervous system, with highest levels in dorsal root ganglion and trigeminal neurons, and lowest levels in sympathetic and enteric neurons, it is not expressed in spinal cord. PIRT is a required component of the VR1 complex, which positively regulates VR1, a sensor of both noxious heat and capsaicin. Correspondingly, PIRT knockout results in impaired responses to noxious heat and capsaicin exposure, while VR1 remains unaltered. The gene that encodes PIRT maps to human chromosome 17p13.1. |
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PIRT Antibody Blocking Peptide(bs-11623P)-500ug
￥880
