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- Bioss
- bs-5109P
- 2025年10月16日
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500ug
| 产品编号 | bs-5109P |
| 英文名称 | HCLS1 Antibody Blocking Peptide |
| 中文名称 | 造血干细胞特异性蛋白封闭多肽 |
| 英文别名 | Cortactin like; CTTNL; HCLS 1; HCLS 1 protein; Hcls1; HCLS1 protein; HCLS1_HUMAN; Hematopoietic cell specific Lyn substrate 1; Hematopoietic cell-specific LYN substrate 1; Hematopoietic lineage cell specific protein; Hematopoietic lineage cell-specific protein; HS 1; HS1; LckBP 1; LckBP1; p75 antibody. |
| 性状 | Lyophilized |
| 纯化方法 | HPLC |
| 研究领域 | Signal Transduction > Adapters > Cytoplasmic |
| 亚基 | Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. Interacts with FES/FPS. Interacts (via SH2 domain) with FGR. Forms a multiprotein complex with LYN and ANKRD54. |
| 亚细胞定位 | Membrane; Peripheral membrane protein. Cytoplasm. Mitochondrion (Probable). |
| 组织特异性 | Expressed only in tissues and cells of hematopoietic origin. |
| 翻译后修饰 | Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES. |
| 相似性 | Contains 4 cortactin repeats.
Contains 1 SH3 domain. |
| 功能 | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. |
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HCLS1 Antibody Blocking Peptide(bs-5109P)-500ug
￥800
