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- bs-15470P
- 2025年10月16日
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500ug
| 产品编号 | bs-15470P |
| 英文名称 | HEXO Antibody Blocking Peptide |
| 中文名称 | 3'-5'外切酶1蛋白封闭多肽 |
| 英文别名 | ERI1; HEXO; THEX1; 3'HEXO; ERI1 exoribonuclease 1; 3' 5' exonuclease ERI 1; 3' 5' exonuclease ERI1; 3' EXO; 3' exoribonuclease; 3' HEXO; 3' histone mRNA exonuclease 1; 3''-5'' exonuclease eri1; 3''-5'' exoribonuclease 1; 3'EXO; 3'HEXO; ERI 1; Eri 1 homolog; Eri-1 homolog; eri1; Eri1 homolog; ERI1_HUMAN; HEXO; Histone mRNA 3' end specific exonuclease; Histone mRNA 3' end specific exoribonuclease; Histone mRNA 3''-end-specific exoribonuclease; Histone mRNA 3''-exonuclease 1; MGC35395; Protein 3''hExo; THEX 1; Three prime histone mRNA exonuclease 1. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromosome Structure > Scaffold Proteins Epigenetics and Nuclear Signaling > DNA / RNA > DNA / Nucleotides |
| 亚基 | Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1. Interacts in a cooperative manner with SLBP to the mature 3'-end of histone mRNAs (By similarity). Binds to 40S and 60S ribosomal subunits and to 80S assembled ribosomes. Found in a ternary complex with SLBP and the stem-loop structure of the 3'-end of histone mRNAs. |
| 亚细胞定位 | Cytoplasm. Nucleus. Nucleus, nucleolus. |
| 相似性 | Contains 1 exonuclease domain. Contains 1 SAP domain. |
| 功能 | RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Helicase with RNase motif, more commonly designated Dicer, cleaves double-stranded RNA (dsRNA) in the RNA interference and small temporal RNA (stRNA) pathways, producing active small RNA components (siRNAs) which target the destruction of RNA and repress gene expression. Human Dicer cleaves dsRNA independent of ATP. The 3’-5’ exonuclease ERI-1, also known as Protein 3'hExo, degrades Histone mRNA after replication and may be involved in the regulation of RNA interference. ERI-1 has a high affinity for the stem-loop structure of replication-dependent Histone pre-mRNAs. It requires the 5'-ACCCA-3' sequence present in stem-loop structure. ERI-1 and a stem-loop binding protein (SLBP) target opposite faces of a unique highly conserved stem-loop RNA scaffold towards the 3' end of Histone mRNA. |
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HEXO Antibody Blocking Peptide(bs-15470P)-500ug
￥880
