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- bs-15469P
- 2025年10月16日
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- 规格：
500ug
| 产品编号 | bs-15469P |
| 英文名称 | HEXIM2 Antibody Blocking Peptide |
| 中文名称 | HEXIM2蛋白封闭多肽 |
| 英文别名 | Hexamethylene bis-acetamide-inducible protein 2; Hexamthylene bis-acetamide inducible 2; HEXI2_HUMAN; hexim 2; HEXIM2; L3; Protein HEXIM2. |
| 纯化方法 | HPLC |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Elongation factors |
| 亚基 | Homooligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed. |
| 相似性 | Belongs to the HEXIM family. |
| 功能 | Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins, which inhibit Positive Transcription Elongation Factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit Cdk9 and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues. |
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HEXIM2 Antibody Blocking Peptide(bs-15469P)-500ug
￥880
